Factors Associated With HIV Infection in Zimbabwe Over a Decade From 2005 to 2015: An Interval-Censoring Survival Analysis Approach

Abstract

Objectives: The main objective of this study was to compare results from two approaches for estimating the effect of different factors on the risk of HIV infection and determine the best fitting model.

Study design: We performed secondary data analysis on cross-sectional data which was collected from the Zimbabwe Demographic Health Survey (ZDHS) from 2005 to 2015.

Methods: Survey and cluster adjusted logistic regression was used to determine variables for use in survival analysis with HIV status as the outcome variable. Covariates found significant in the logistic regression were used in survival analysis to determine the factors associated with HIV infection over the 10 years. The data for the survival analysis were modeled assuming age at survey imputation (Model 1) and interval-censoring (Model 2).

Results: Model goodness of fit test based on the Cox-Snell residuals against the cumulative hazard indicated that Model 1 was the best model. On the contrary, the Akaike Information Criterion (AIC) indicated that Model 2 was the best model. Factors associated with a high risk of HIV infection were being female, number of sexual partners, and having had an STI in the past year prior to the survey.

Conclusion: The difference between the results from the Cox-Snell residuals graphical method and the model estimates and AIC value maybe due to the lack of adequate methods to test the goodness-of -fit of interval-censored data. We concluded that Model 2 with interval-censoring gave better estimates due to its consistency with the published results from literature. Even though we consider the interval-censoring model as the superior model with regards to our specific data, the method had its own set of limitations.